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It produces clusters of purple, blue, and white flowers, and it's famous for its long . Dosage: How Much Comfrey Cream Should I Use? What Happens If I Use Too Much Comfrey Cream? Using a combination product makes it challenging to know how much of the beneficial effect came from comfrey alone. This is because only a small amount of the pyrrolizidine alkaloids are absorbed through the skin (. Comfrey is avoided on cuts or puncture wounds for this reason. As we are constantly reviewing and developing our products to meet our consumer needs, consumers, particularly those that suffer from allergies and intolerances, should always check product labelling, warnings, and directions provided with the product that is delivered, prior to use or consumption. For one of these studies, the average time participants had experienced knee pain and stiffness leading up to the study was six and a half years! Comfrey (Symphytum officinale) is a plant with yellow or purple flowers found in Europe, Asia, and North America. Other prescription medicines that may harm the liver include: Some supplements may also harm the liver, including: It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Do not take comfrey without medical advice if you are using any of the following medications: This list is not complete. Potter's Herbals Comfrey Ointment for Minor Sprains and Bruises Call your doctor for medical advice about . Glass bowl with a lid Retrieved from, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=295. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. This perennial can grow up to 4-feet tall. Penetration of lycopsamine from a comfrey ointment through human epidermis. Transfer the cooled oil and butter mixture to a standing electric mixer or blender. 2007;157(21-22):569-574. Wien.Med Wochenschr. Affiliate links are shared throughout the website and the Herbal Academy may receive compensation if you make a purchase with these links. doi:10.1002/14651858.CD010538, Smith DB, Jacobson BH. An ankle sprain can come out of nowhere and cause a lot of pain, limitations, and regret until it is healed. Kuera, M., Barna, M., Horek, O., Kovrikov, J., & Kuera, A. D'Anchise, R., Bulitta, M., and Giannetti, B. Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). Comfrey - Memorial Sloan Kettering Cancer Center This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Comfrey root extracts have been used by herbalists and in folk traditions for centuries to soothe aches and pains. Please simply create an account before buying/booking any courses. What are the benefits of using it? Comfrey oil should be applied topically to parts of the body where you have muscular pain or discomfort. (2018). View abstract. Copyright Holland & Barrett Retail Limited, 2022. Comfrey cream Stewart MJ, Steenkamp V. Pyrrolizidine poisoning: a neglected area in human toxicology. This article discusses the uses and benefits of comfrey cream. Navarro VJ, Khan I, Bjrnsson E, Seeff LB, Serrano J, Hoofnagle JH. This is not recommended due to the presence of chemicals that can cause organ damage and cancer. Please read the Topical Use Safety section of this article (above) before using. A member of the borage family, comfrey root, leaves, and stems have an obvious coat of bristly hair. Pyrrolizidine poisoning. 2008;54(1):7-20. We comply with the HONcode standard for trustworthy health information. View abstract. To make this recipe, first, you must prepare the comfrey root tincture. Experts suggest not using comfrey cream for longer than ten days in a row. As we are constantly reviewing and developing our products to meet our consumer needs, consumers, particularly those that suffer from allergies and intolerances, should always check product labelling, warnings, and directions provided with the product that is delivered, prior to use or consumption. J Chin Med.Assoc. What is niacinamide? 2004;154(21-22):498-507. Bleakley, C. M., McDonough, S. M., and MacAuley, D. C. Some conservative strategies are effective when added to controlled mobilisation with external support after acute ankle sprain: a systematic review. Stam, C., Bonnet, M. S., & van Haselen, R. A. In another study, participants with ankle sprains received either comfrey root extract cream or diclofenac gel, a nonsteroidal anti-inflammatory drug (NSAID). Topically applied comfrey oil is associated with a wide range of health benefits and can help with certainissues including: Comfrey oil is good at helping with superficial cuts, scratches, and scrapes. Available at: https://www.cfsan.fda.gov/~dms/dspltr06.html. Its long, lance-shaped leaves can be up to 1 foot in length closer to the bottom of the stem and are shorter higher up the stem. View abstract. This item: Terry Naturally Traumaplant Comfrey Cream - 1.76 oz (50 g) - Non-Staining Topical Botanical, Free of Toxic Pyrrolizidine Alkaloids (PAs) & Parabens - for External Use Only $20.76 ($11.80/Ounce) Dr. Christopher's Comfrey Ointment, 2 Ounce $11.99 ($6.00/Ounce) Dr Christopher's Formula Complete Tissue and Bone Ointment, 4 Ounce 2012;101(4):211-216. Choose organically grown comfrey when possible. View abstract. 1 Since at least the 4 th century, people have used comfrey medicinally. OTHER NAME(S): Ass Ear, Black Root, Blackwort, Bruisewort, Common. Herbal drugs and phytopharmaceuticals. Click to share on Facebook (Opens in new window), Click to share on Pinterest (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Tumblr (Opens in new window), Click to share on Reddit (Opens in new window), Click to email a link to a friend (Opens in new window), Try A Cooling Herbal Compress for Hot Summer Days, Handmade Floral Paper: A Family-Friendly Project, Making Herbal Preparations 101 Mini Course, Emulsifiers and Preservatives in Botanical Skin Care Products. Avoid taking comfrey orally (by mouth). Learn more in The Comfrey Controversy: Can and Should One Use Comfrey Internally? (10), 707-714. https://doi.org/10.1016/j.phymed.2005.06.001. Vickers AJ, Vertosick EA, Lewith G, et al. In a multicenter, randomized, double-blind, placebo-controlled study with 142 ankle sprain participants, a comfrey root extract applied 4x/day for 8 days improved pain, swelling, and mobility without any adverse reactions (Koll et al., 2004). Mazzocchi, A. and Montanaro, F. Observational study of the use of Symphytum 5CH in the management of pain and swelling after dental implant surgery. 2013;21(6):724-45. Phytother.Res 2012;26(10):1441-1448. As the consistency thickens some more, turn the mixer up a little bit more. You may report side effects to FDA at 1-800-FDA-1088. Amendments to the poison list. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., & Staiger, C. (2004). (2001). We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. 1. Consult with a licensed healthcare professional before using any herbal/health supplement. How to Make and Use Comfrey Fertilizer - The Spruce Stop using comfrey and call your healthcare provider at once if you have: liver problems-- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). 2013;163(3-4):58-64. Phytomedicine, 12(10), 707-714. https://doi.org/10.1016/j.phymed.2005.06.001, Smith, D. B., & Jacobson, B. H. (2011). 2010;44(9):637-41. doi:10.1136/bjsm.2009.058677, Cameron M, Chrubasik S. Topical herbal therapies for treating osteoarthritis. The Pharmaceutical Journal, PJ, December 2007. As an additional measure of efficacy, groups instructed to use the comfrey preparation for the longest period of time experienced the most improvement. The recipe makes about 6 small jars. View abstract. Squish and squeeze as many leaves into as you can into the container. 2017;65(1):363-373. doi:10.1002/hep.28813. Efficacy and tolerance of a comfrey root extract (Extr. Simply massage into the skin as required. cbd cream holland and barrett for pain relief HTB; 2021 2; Youtube; Twitter; Facebook; ; The leaves and stems of comfrey contain pyrrolizidine alkaloids that can cause toxic damage if ingested in excess (Ulbricht, 2010). Browse our Sports Hub, Get 20% student discount with Student Beans, Discover the latest natural beauty products, Buy 1 get 1 Half Price on Vitamins & Supplements, Popular Vitamins & Supplements Subscriptions, Buy 1 get 1 Half Price gut health supplements, Guide to sleeping better natural sleeping remedies, Living in the now, gut health & mental wellbeing, The thing that makes you different makes you special, For the symptomatic relief of minor sprains and bruises, Contains Comfrey which is known for its healing properties. Osteoarthritis Cartilage. Comfrey ( Symphytum officinale) is an attractive ornamental plant used in gardening and medicine. The Comfrey Ointment that I have been using is to be used only for sprains and bruises. (2004). Make sure to always buy comfrey. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., Giannetti, B., Klingenburg, S., and Staiger, C. Efficacy and tolerance of a comfrey root extract (Extr. Kucera, M., Barna, M., Horacek, O., Kovarikova, J., and Kucera, A. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study. ). However, not a rate considered harmful for those with healthy livers.10,11, Masters Degree in Toxicology and BSc Hons in Medical Biochemistry. Company number 02758955 Registered VAT number 211727395. To make the cream, combine sunflower oil, safflower oil, coconut oil, and cocoa butter in a double-boiler over low heat until completely melted. Whenselecting a brand of supplements, look for products certified by Consumer Labs, the U.S.Pharmacopeia, or NSF. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: Results of a double-blind, randomised, placebo controlled, multicentre trial. Thank you, {{form.email}}, for signing up. With extract of Comfrey. Would you like to win our brilliant Botanical Business Package with nearly $1,000 in prizes? What Are the Side Effects of Comfrey Cream? . Adv Ther 2005;22(6):681-692. https://doi.org/10.1007/s10354-007-0474-y. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Medicinal use of this product has not been approved by the FDA. Centurian, South Africa: Medpharm Scientific Publishers. J Hepatol 2003;39:437-46. Phytomedicine, 14(1), 2-10. https://doi.org/10.1016/j.phymed.2006.11.006, Jedlinszki, N., Balzs, B., Csnyi, E., & Csupor, D. (2017). Other uses not proven with research have included skin wounds, skin ulcers, cough, sore throat, gum disease, joint pain, diarrhea, and other conditions. It is easily absorbed to leave your skin feeling fresh, soft and radiant. Holland Barrett | Careers After testing their 1000mg CBD oil drops for over a month, we now have little question this is the best CBD oil within the UK as of 2019. This is not a complete list of side effects and others may occur. Comfrey has been cultivated as a green vegetable and has been used as an herbal medicine for more than 2,000 years. Megan Nunn, PharmD, is a community pharmacist in Tennessee with twelve years of experience in medication counseling and immunization. The comfrey plant, Symphytum officinale, gets its name from the Latin confervere, meaning to grow together. They help us to understand how people use the website and give us the ability to provide targeted marketing to you. Phytother Res. Mix for about 10 minutes, until nice and whipped. View abstract. Its long, lance-shaped leaves can be up to 1 foot in length closer to the bottom of the stem and are shorter higher up the stem. Eucalyptus oil is used externally to stimulate blood flow. State Level Environment Impact Assessment Authority, Jharkhand This comfrey cream recipe works great for local areas that have mild bruising or soft tissue pain. For topical comfrey cream, look for products labeled as free of pyrrolizidine alkaloids. byBhupesh Panchal, Senior Regulatory Affairs Associate, Comfrey oil is a herbal oil that moisturises skin, and thats been used as a healing herb for a long time.1, Since at least the 4th century, people have used comfrey medicinally. Dietary Supplements: What You Need to Know. You can purchase the Comfrey Ointment at Boots, Tesco, Sainsbury's or Holland & Barrett. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Be sure to choose organic carrier oils and essential oils when possible. Double boiler Heat oil in double boiler gently then add beeswax until it melts. View abstract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Gyorik, S. and Stricker, H. Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy. This information may not fit your specific health circumstances. Do not use extra comfrey to make up the missed dose. No supplement is intended to treat, cure, or prevent disease. Efficacy of a comfrey root (Symphyti offic. Fitoterapia. Oral use of comfrey is not recommended because of potential liver damage. Phytother Res. Information offered on Herbal Academy websites is for educational purposes only. Whether youve been hiking, biking, playing, or enjoying water sports, comfrey cream can be a wonderful ally in supporting achy muscles that result from physical, summertime activities. Tolerability and effectiveness of an antitrauma cream with comfrey herb extract in pediatric use with application on intact and on broken skin. Therapeutic Research Faculty 2020. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 2012;20(11):1209-16. doi:10.1016/j.joca.2012.07.019, Zago LR, Prado K, Benedito VL, Pereira MM. After 2-4 weeks have passed, strain the root from the alcohol using a coffee filter inserted in a wire mesh strainer or similar setup. Comfrey contains chemicals that cause serious liver damage when taken by mouth. Frost R, Macpherson H, O'meara S. A critical scoping review of external uses of comfrey (Symphytum spp.). Cochrane Database Syst Rev. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. Comfrey contains chemicals called. Using a supplement like comfrey may have potential side effects. Z Phytotherapie 2000;21:127-134. . A large review released in 2013 about the medicinal uses of comfrey stated: It is clinically proven to relieve pain, inflammation and swelling of muscles and joints in the case of degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after . Public Health Nutr 2000;3:501-8. Can a comfrey (Symphytum officianale) root extraction help ease aching joints and muscles? Nutrition C for FS and A. Regul Toxicol Pharmacol. comfrey cream holland and barrett - daxasys.com Efficacy of a comfrey root (Symphyti offic. They help us to understand how people use the website and give us the ability to provide targeted marketing to you. A review of 26 clinical trials concluded that mild skin reactions were the most common side effects of comfrey creams used in the studies. The Food and Drug Administration (FDA) released an advisory in July 2001 recommending that comfrey products be removed from the market because of cases of hepatic veno-occlusive disease. Therapeutic use of comfrey is limited because of its toxicity. Also, avoid use for more than two weeks or excessive concentrations containing more than 100 mcg of pyrrolizidine alkaloids (Wichtl, 2004 & Ulbricht, 2010). 20 Rewards for Life points with this purchase, Potters Herbals Comfrey Ointment is a traditional herbal medicinal product used for the symptomatic relief of minor sprains and bruises, based on traditional use only. Our Two Pennies Worth. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. Additionally, there is scientific research demonstrating comfreys effectiveness at soothing muscle and joint pain, some of which are highlighted in this post. View abstract. Metabolism, genotoxicity, and carcinogenicity of comfrey. View abstract. Adv.Ther 2000;17(4):204-210. Effects of Symphytum ointment on muscular symptoms and functional locomotor disturbances. Sometimes, massaging on topical ointments can help reduce pain and inflammation. NIH Office of Dietary Supplements. 2020;142:104519. Looks like you may need to upgrade your browser We're sorry, we no longer support the web browser that you are using Natural Standard. And topical capsaicin cream may help to relieve pain temporarily. Limited trials have evaluated the effectiveness of alkaloid-free preparations for external use; however, these studies did not examine how much liver damage occurred in patients. Cover, but leave a small air opening. WebMD does not provide medical advice, diagnosis or treatment. 98% Naturally derived. Comfrey Cream: Uses, Benefits, Side Effects, Dosage - Verywell Health New South Wales Health, Australia. NCCIH. 2013;21(6):724-745. doi:10.1016/j.ctim.2013.09.009. British journal of sports medicine, 44(9), 637-641. https://doi.org/10.1136/bjsm.2009.058677, Grube, B., Grnwald, J., Krug, L., & Staiger, C. (2007). Most comfrey oils keep for around 2 years after production. *PR sample. Smith, D. B., & Jacobson, B. H. (2011). Copyright Holland & Barrett Retail Limited, 2022. Rad. Swiss.Med.Wkly. All rights reserved. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: Results of a double-blind, randomised, bicenter, placebo-controlled trial. Do not use this product without medical advice if you are breast-feeding a baby. Complement Ther Med. Frost R, O'meara S, Macpherson H. The external use of comfrey: a practitioner survey. In a small study with 30 subjects, lower back pain from exercise was reduced with an ointment containing comfrey. (Grube et al., 2007). Arzneimittelforschung. In 2001, the Food and Drug Administration (FDA) banned oral comfrey products. (2013). Pyrrolizidine alkaloids are very toxic to the liver and are also carcinogenic (cause cancer). J Chiropr Med. Store at room temperature away from moisture and heat. Homeopathy. It has bell-shaped red-violet or yellowish flowers. View abstract. Like any new treatment, discontinue use if any irritation occurs. A limited number of clinical trials show short-term efficacy of topically applied, alkaloid-free comfrey preparations in skin abrasions and inflammatory conditions. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Be sure to use comfrey root from a reputable source that has properly identified the species. Check regularly, but it should take about six weeks for all the leaves to break down into a thick, black liquid. The way that they work is by blocking small blood vessels in the liver. Symphyti) in the treatment of ankle distorsions: Results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine, 11(6), 470-477. https://doi.org/10.1016/j.phymed.2004.02.001, Kucera, A., Barna, M., Holcova, S., Horacek, O., Hladikov, M., & Ottillinger, B. Vithayathil MK, Edwards M. Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis. , 43 volunteers with osteoarthritis used either a topical cream containing comfrey, tannic acid, and eucalyptus or a placebo cream 3x/ day for 6 weeks. Registered in England: company no. You can weight them down with a rock or brick. A member of the borage family, comfrey root, leaves, and stems have an obvious coat of bristly hair. Grube, B., Grnwald, J., Krug, L., & Staiger, C. (2007). Smith DB, Jacobson BH. Wien Med Wochenschr. Grube, B., Grunwald, J., Krug, L., and Staiger, C. Efficacy of a comfrey root (Symphyti offic. However, people with knee pain may be glad to try a topical preparation that could help in addition to any other recommendations made by their physician. J Agric.Food Chem 2001;49(8):3942-3946. WMW Wiener Medizinische Wochenschrift, 154(21), 498-507. https://link.springer.com/article/10.1007/s10354-004-0114-8, Natural Medicines (2020). A critical scoping review of external uses of comfrey (Symphytum spp.). Book your free, one-to-one online consultation with one of our qualified advisors. The roots and leaves of the comfrey plant have medicinal properties. J Pharmacopuncture 2021;24(4):196-205. J Chiropr Med. Be sure to choose organic carrier oils and essential oils when possible. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. Discard after a year or according to labeling. For this reason, some topical products are advertised as made from comfrey leaves, but it's safest to choose a PA-free product. Influence of moderate physical exertion on subacute low back pain, after Symphytum officinale ointment treatment. Comfrey has also been used for the following conditions: There is currently not enough evidence to recommend comfrey cream for any of these uses. Complementary Health Approaches for Chronic Pain: What the Science Says. Call your doctor for medical advice about side effects. comfrey cream holland and barrett - mail.empower.tn It's found in Europe, Asia, and North America. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. Registered VAT no. Giannetti, B. M., Staiger, C., Bulitta, M., and Predel, H. G. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Bhupesh started his career as a Clinical Toxicologist for Public Health England, advising healthcare professionals all around the country on how to manage clinical cases of adverse exposure to supplements, pharmaceuticals, cosmetics, industrial chemicals and agricultural products. Modern science suggests that the ancients were correct in believing comfrey helps to heal woundsand relieve pain.3,4 In this article, well explain where comfrey comes from, comfrey oils remarkable health benefits and how to use it at home. Do not use this product if you have a sensitivity to any of the ingredients. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Many have said that it has helped them with a variety of aches and pains! 2010;44(9):637-641. Potters Comfrey Ointment | Holland & Barrett The Effect of Comfrey on Enoxaparin-Induced Bruise in Patients with Acute Coronary Syndrome: A Randomised Clinical Trial. Latest: Senior Software Engineer - Front End Senior Software Engineer Senior Product Manager - Basket, Checkout and Payments UX Designer - Instore Tech. This is memorable if you have worked with it, and some use this quality to remember comfreys centuries-long useapplying comfrey over bones, bruises, sprains, and minor wounds with the intention to support mending! We cover all you need to know in this article. Healthy adults: massage about 1 teaspoon of cream into a local area up to 4x/day for up to 2 weeks. After the tincture is made, then you can whip up the fabulous joint and muscle cream! Instructions. Label with the ingredients and date made. Comfrey Cream Recipe for Achy Joints and Muscles - Herbal Academy Version: 5.01. It also covers side effects, interactions, and what to look for. 1.35 Fl Oz. Comfrey Uses, Side Effects & Warnings - Drugs.com To Use. Comfrey has been used in alternative medicine as a possibly effective aid in treating back pain, osteoarthritis, or tenderness and swelling caused by a sprain injury. Researchers have investigated the effects of comfrey cream on several health conditions. Medicine makers would bind comfrey leaves and roots in poultices, then apply those poultices to the skin to treat injuries. What alternatives to comfrey cream are there for back pain? 2012;62(6):285-289. Drug-induced liver injury. Drugs and Lactation Database (LactMed). Yield: Approximately 5 cups of whipped lotion. Ministry of Environment & Forests, Govt. Brassica Campest is Seed Oil (Rapeseed Oil), Symphytum Officinale Herb (Comfrey Herb), BHA, Eucalyptus Globulus Leaf Oil (Eucalyptus Oil). The warm weather has a way of encouraging us to get outside and move our bodies more. View abstract. Comfrey root: from tradition to modern clinical trials, Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial, Topical herbal therapies for treating osteoarthritis, Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials, Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. Store comfrey cream according to package instructions, typically at room temperature and out of reach of children and pets. Avila C, Breakspear I, Hawrelak J, Salmond S, Evans S. A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale). The plant has a long history in folk and ancient herbal treatments before comfrey is . Information from this source is evidence-based and objective, and without commercial influence. Using different formulations together increases the risk of an overdose. Finally, well warn of any side effects associated with comfrey oil. A handbook for practice on a scientific basis. A symptomatic treatment of minor sprains and bruises. Wichtl, M. (2004). Comfrey oil is made by infusing the leaves and roots of a comfrey plant with a neutral oil. Lorem ipsum dolor sit nulla or narjusto laoreet onse ctetur adipisci. We're proud to make a difference, and you can to. Comfrey has been used medicinally for at least 2000 years for various conditions, including bone fractures, ulcers, and gout. View abstract. Comfrey can also contain echimidine, pyrrolizidine alkaloids (PAs), and symphytine, which can damage the liver, are carcinogenic (cancer-causing) and may harm a fetus. International Journal of Pediatrics and Adolescent Medicine, (4), 135-141. https://doi.org/10.1016/j.ijpam.2018.11.002. A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale). Avoid using comfrey together with other herbal/health supplements that can also harm the liver. Available for Android and iOS devices. comfrey cream holland and barrettfeathered friend questions and answers. Other drugs may interact with comfrey, including prescription and over-the-counter medicines, vitamins, and herbal products. Barna, M., Kucera, A., Hladicova, M., and Kucera, M. [Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study].